Found inside – Page 586In high doses, the drug can be nephrotoxic and cause dermatitis, ... Widemann BC, Adamson PC: Understanding and managing methotrexate nephrotoxicity, ... Found insideHowever, highdose methotrexate regimens (50–250 mg/kg to 1–7 gm/m2) have been associated with a greater incidence of nephrotoxicity [36]. Found inside – Page 1165Exacerbation of renal dysfunction can occur with nephrotoxic agents (e.g., ... mesna Appropriate hydration RENAL FAILURE Methotrexate nephrotoxicity occurs ... Found inside – Page 299Methotrexate-induced nephrotoxicity is typically an acute treatment side effect and Anthracycline dose Recommended frequency None Every 2 years Any Every ... Found inside – Page 138Nephrotoxicity is not a concern with low or standard dose methotrexate, but at high doses the drug and its metabolites can crystallize in the tubular lumina ... Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Found inside – Page 1305Highdose methotrexate-induced nephrotoxicity in patients with osteosarcoma. Cancer. 2004;100(10):2222-2232. Flombaum C, Meyers P. High-dose leucovorin as ... Found inside – Page 405Thus, methotrexate toxicity may manifest as multiple organ failure [13]. Prevention of nephrotoxicity, together with methotrexate level monitoring, ... Found inside – Page 144Mechanism of Action Methotrexate can be given orally or by injection. ... not associated with nephrotoxicity, unless underlying kidney disease is present. Found inside – Page 23Carboxypeptidase-G2 rescue in a patient with high dose methotrexate-induced nephrotoxicity. Cancer Res Treat. 2005;37(2):133-135. 9. Peyriere H, Cociglio M, ... Found inside – Page 2290Methotrexate-Induced Renal Dysfunction Because methotrexate is usually cleared exclusively by the kidneys, nephrotoxicity associated with high-dose ... Found inside – Page 12688Synthesis of the 7 - hydroxy metabolites of methotrexate and Med Pediatr Oncol ... methotrexate nephrotoxicity : nonrenal excretion of serum detection ? Found inside – Page 380Mitomycin C- induced nephrotoxicity carries significant mortality, with associated pulmonary ... Methotrexate Methotrexate is a widely used anticancer drug. Found inside – Page 783It is postulated that there is some subclinical nephrotoxic effect of indomethicin that inhibits rapid and complete elimination of large methotrexate doses. Found inside – Page 145NEPHROTOXICITY WITH CHEMOTHERAPEUTIC AGENTS Chemotherapeutic agents reported to cause impairment of renal function include cisplatin , methyl CCNU ( 1 , 2 - chlorethyl - 3 , 4 - methylcyclohexyl - 1 - nitrosourea ) , methotrexate ... Found insideMethotrexate nephrotoxicity is dose-dependent but usually moderate and reversible.27 In a study28 of 102 patients treated with high-dose methotrexate, ... Found inside – Page 179Difficulty measuring methotrexate in a patient with high-dose methotrexate-induced nephrotoxicity. Clin Chem. 2010;56(12):1792–4. Berg JM, Tymoczko JL, ... Found inside – Page 1140Nephrotoxicity associated with high-dose methotrexate administration can be considered a true oncologic emergency. Although the strategies of hydration, ... Found inside – Page 824Because of the primary renal rate of excretion and the possibility of nephrotoxicity, methotrexate should be withheld or administered at reduced doses in ... Found inside – Page 280In patients in whom bisphosphonate nephrotoxicity is a major concern, ... Once methotrexate nephrotoxicity develops, reduced elimination of the drug ... Found inside – Page 336... et al : Nephrotoxicity of nitrosoureas . Cancer 48 : 1328 – 1334 , 1981 54 . Hande KR , Donehower RC , Chabner BA : Pharmacology and pharmacokinetics of high - dose methotrexate in man , in Pinedo HM ( ed ) : Clinical Pharmacology of ... Found inside – Page 206... management of methotrexate toxicity. J Med Toxicol 2008;4(2):132e40. Widemann BC, Adamson PC. Understanding and managing methotrexate nephrotoxicity. Found inside – Page 216WHAT TO DO: EVALUATE Methotrexate is a widely used therapy in adult and pediatric ... oncology: Understanding and managing methotrexate nephrotoxicity. Found inside – Page 119Nitrosoureas Streptozotocin is a highly nephrotoxic drug and could induce ... Methotrexate With low conventional doses, nephrotoxicity of methotrexate ... Found inside... 4amino4deoxyN10methylpteroic acid (DAMPA),526 rescues patients who develop methotrexate nephrotoxicity by providing an alternative route of ... Found inside – Page 13001 * Incomplete urine collection * * Percent of drug excreted as metabolite and may contribute to methotrexate - related nephrotoxicity . However , the precise pharmacological and toxicological significance of this metabolite remains to be ... Found inside – Page 21900 Methotrexate - Procarbazine Significance : 2 — moderately clinically significant Potential Effects : Procarbazine may predispose patients to nephrotoxicity with concurrent methotrexate . Recommendations : Consideration should be given to ... Found insideUrinary beta2 may be a useful marker of methotrexate nephrotoxicity (62). When serum methotrexate concentrations are high, leucovorin (folinic acid) rescue ... Found inside – Page 24The nephrotoxicity of cisplatin is reduced in humans [73], mice [74] and dogs [75] ... In human, methotrexate is largely cleared unchanged from the body by ... Found insideNitrosoureas Streptozotocin is the most nephrotoxic drug in the group of ... Methotrexate may be nephrotoxic when doses higher than 1000 mg/m 2 are used; ... Found inside – Page 537Cisplatin-induced nephrotoxicity is both cumulative and dose related. ... Methotrexate is not usually nephrotoxic, although 90% of the drug is excreted ... Found inside – Page 133The risk of methotrexate nephrotoxicity is reduced greatly by prophylactic intravenous fluid and alkalinization regimens to prevent tubular ... Found inside – Page 824Because of the primary renal rate of excretion and the possibility of nephrotoxicity, methotrexate should be withheld or administered at reduced doses in ... Membrane transporters are important determinants of drug disposition and response. Found inside – Page 824Because of the primary renal rate of excretion and the possibility of nephrotoxicity, methotrexate should be withheld or administered at reduced doses in ... Found inside – Page 26Administration of high doses of methotrexate as in the treatment of ALL or osteosarcoma may also result in nephrotoxicity due to the precipitation of ... Found inside – Page 159Methotrexate-induced renal impairment: clinical studies and rescue from systemic toxicity with ... Understanding and managing methotrexate nephrotoxicity. Found inside – Page 893Methotrexate tends to accumulate in third-space fluids (e.g., ... The risk of methotrexate nephrotoxicity is significantly reduced by ensuring adequate ... Found inside – Page 352Several measures may be used to lessen the incidence of methotrexate nephrotoxicity . First , the concentration of the drug in urine can be decreased by maintaining extracellular fluid volume expansion and a high urine flow rate ( > 100 mL / h ... Found inside – Page 48Chabner BA (1996) Concepts in use of high-dose methotrexate therapy: Clin Chem 42 ... J Clin Oncol 9: 670–674 Fox RM (1979) Methotrexate nephrotoxicity. Found inside – Page 609Methotrexate nephrotoxicity occurs primarily through the formation of crystals in renal tubules, which causes tubular toxicity and obstruction.33 Because ... Found inside – Page 21... it is unsurprising that other potentially nephrotoxic chemotherapy (e.g. ... information about the frequency of chronic methotrexate nephrotoxicity. Found inside – Page 961Carboxypeptidase-G2 rescue in a patient with high dose methotrexate-induced nephrotoxicity. Cancer 1995; 76(3): 521–6. Krackhardt A, Schwartz S, Korfel A, ... Found inside – Page 301Incidence of drug - related deaths secondary to high - dose methotrexate and citrovorum factor administration . Cancer Treat Rep 1977 ; 61 : 745 – 748 . 130 . Fox RM : Methotrexate nephrotoxicity . Clin Exp Pharmacol Physiol 1979 ; ( suppl ) 5 ... Found inside – Page 317Methotrexate nephrotoxicity can lead to delayed elimination of the drug and the development of life-threatening toxicity. Methotrexate is fully ionized at ... Found inside – Page 383Understanding and managing methotrexate nephrotoxicity. Oncologist. 2006;11:694-703. Jacobs SA, Stoller RG, Chabner BA, et al. 7-Hydroxymethotrexate as a ... Found inside – Page 202At conventional doses, the nephrotoxic potential of methotrexate is very low. However, with the introduction of high-dose therapy of 1–7 g/m with leucovorin ... Lessen the incidence of methotrexate nephrotoxicity nephrotoxicity can lead to delayed elimination of the drug and development. Frequency of chronic methotrexate nephrotoxicity Page 352Several measures may be used to lessen the incidence of nephrotoxicity! ; 61: 745 – 748 cancer 48: 1328 – 1334, 54! Methotrexate toxicity may manifest as multiple organ failure [ 13 ] 1977 ; 61 745. 352Several measures may be used to lessen the incidence of methotrexate nephrotoxicity methotrexate administration can be considered a oncologic... 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