Oncolytic virus (OV) therapy is an experimental form of biological therapy has shown increasing potential over the last decade, culminating with the first FDA approval of an OV therapy, the Herpes simplex virus Talimogene laherparepvec (T ... Found inside – Page 195Talimogene laherparepvec for treating unresectable metastatic melanoma. Technology appraisal guidance TA410. Available from: www.nice.org.uk/guidance/ta410 ... Found inside – Page 38Cutaneous head and neck melanoma in OPTiM, a randomized phase 3 trial of talimogene laherparepvec versus granulocytemacrophage colony-stimulating factor for ... Found inside – Page 48Talimogene laherparepvec is an oncolytic immunotherapy comprising a modified HSV type 1 engineered to selectively replicate in tumor cells and to express ... Found inside – Page 523Talimogene Laherparepvec improves durable response rate in patients with advanced melanoma. J Clin Oncol. 2015;33:2780–8. Liu B, Robinson M, Han Z, et al. Found inside – Page 1032Of the group given talimogene laherparepvec, 16.3% showed a durable response of greater than 6 months, with some responses extending past 3 years. Found inside – Page 23Talimogene Laherparepvec in Combination With Ipilimumab in Previously Untreated, Unresectable Stage IIIB-IV Melanoma. J. Clin. Oncol. 2016, 34, 2619–2626. Found insideTalimogene laherparepvec improves durable response rate in patients with ... Franke V. Talimogene laherparepvec monotherapy, an elegant alternative to ... Found insideBackground: Talimogene laherparepvec is an oncolytic immunotherapy based on a modified herpes simplex virus type 1 (HSV-1), designed to kill neoplastic ... Found inside – Page 429Talimogene laherparepvec improves durable response rate in patients with advanced melanoma. J Clin Oncol 2015;33:2780–8. 9. Senzer NN, Kaufman HL, ... Found inside – Page 733Talimogene laherparepvec improves durable response rate in patients with advanced melanoma. J Clin Oncol. 2015;33:2780–2788. 30. Chesney J, Puzanov I, ... Found inside – Page 277Real-world outcomes of talimogene laherparepvec therapy: a multi-institutional experience. J Am Coll Surg. 2019;228(4):644–9. 9. Masoud SJ, Hu JB, ... Found inside – Page 129Talimogene laherparepvec in combination with ipilimumab in previously untreated, unresectable stage IIIB-IV melanoma. J Clin Oncol (2016) 34(22):2619–26. Found inside – Page 407Talimogene Laherparepvec for the Treatment of Advanced Melanoma. Clin Cancer Res. 2016;22(13):3127–3131. Andtbacka RH, Kaufman HL, Collichio F, et al. Found insideTalimogene laherparepvec improves durable response rate in patients with advanced melanoma. J Clin Oncol 2015;33(25):2780–2788. Chesney J, Puzanov I, ... Found inside – Page 1033While talimogene laherparepvec is sensitive to acyclovir, it or other antiviral agents may decrease the effectiveness of talimogene laherparepvec. Found inside – Page 66Talimogene laherparepvec: first in class oncolytic virotherapy. Hum Vaccin Immunother. 2018;14(4):839–46. Andtbacka RH, Kaufman HL, Collichio F, Amatruda T, ... Found inside – Page 1239Reinitiate talimogene laherparepvec if new, unresectable cutaneous, subcutaneous, or nodal lesions appear after a CR. Drug Preparation: • Healthcare ... This book provides state-of-art and authoritative coverage of nearly 100 tumor syndromes, with chapters presenting overviews of individual tumor syndromes in relation to their biology, epidemiology, pathogenesis, clinical features, ... Found inside – Page iThis book focusses on the different types of immunotherapeutics that are currently being used and developed for the treatment of melanoma. Found inside – Page 169NCI FDA Approves Talimogene Laherparepvec to Treat Metastatic Melanoma. https://www.cancer.gov/news-events/cancer-currents- blog/2015/t-vec-melanoma. 9. Found inside – Page 401Talimogene laherparepvec improves durable response rate in patients with advanced melanoma. J Clin Oncol 2015;33(25):2780–8. doi:10.1200/ JCO.2014.58.3377. Found inside – Page 50While ipilimumab, pembrolizumab, and nivolumab act by blocking immuneinhibitory signals, Talimogene Laherparepvec (T-VEC) is an oncolytic virus that, ... Found insideTalimogene laherparepvec is a modified herpes simplex virus 1 oncolytic virus that replicates within malignant melanoma cells and activates the innate ... Found inside – Page 469Use of Talimogene Laherparepvec (T-VEC) Viral Oncolytic Immunotherapy in Melanoma Talimogene laherparepvec (T-VEC) is a modified herpes virus that is ... Found insideThese new breakthroughs, now approved by the FDA, are a part of multiple phase III international trials and ongoing research in malignant glioma, meaning that the information in this cutting-edge book will be of great importance to ... Found inside – Page 443Talimogene laherparepvec improves durable response rate in patients with advanced melanoma. J Clin Oncol 2015;33(25):2780–8. 35. Andtbacka RHI, Collichio F, ... Found inside – Page 288Talimogene laherparepvec improves durable response rate in patients with advanced melanoma. J Clin Oncol. 2015;33:2780–8. 54. Puzanov I, Milhem MM, Minor D, ... Found inside – Page 259Talimogene laherparepvec (IMLYGICTM) has become the first world class of novel agents known as oncolytic ... Found inside – Page 29A. Talimogene laherparepvec Talimogene laherparepvec (T-VEC) is an FDA-approved injectable treatment for inoperable melanoma. It is an oncolytic herpes ... Found inside – Page 250Talimogene Laherparepvec Talimogene laherparepvec (T-VEC) is an intratumorally administered oncolytic viral immunotherapy that is approved by the US Food ... Found inside – Page 125Randomized, open-label phase ii study evaluating the efficacy and safety of talimogene laherparepvec in combination with ipilimumab versus ipilimumab alone ... Found inside – Page 167IMLYGIC (talimogene laherparepvec) is a sterile suspension for intralesional injection. IMLYGIC is a live, attenuated HSV-1 that has been genetically ... Found inside – Page 334Talimogene. Laherparepvec. The JS1 strain of HSV-1 was originally isolated from a cold sore in a reactivated infection and was selected for clinical ... Injections -- Interleukin-2 -- Talimogene Laherparepvec -- Rose Bengal (PV-10) -- Interferon -- Bacillus Calmette-Guérin -- Electrochemotherapy -- Summary -- References -- Chapter 14: Surveillance and Follow-Up -- Introduction -- Risk of ... The book, drawing on data from the entire Italian experience as well as world literature, will be an outstanding benchmark for health professionals and researchers. Found inside – Page 59Typical human PK studies are not relevant for the oncolytic virus talimogene laherparepvec. The pharmacology of talimogene laherparepvec is defined by the ... Found inside – Page 116Talimogene laherparepvec and radiation therapy in treating patients with newly diagnosed soft tissue sarcoma that can be removed by surgery. Found inside – Page 1009Talimogene Laherparepvec Talimogene laherparepvec (T-VEC) is an oncolytic herpes simplex virus encoded with the gene for GM-CSF. Found insideTalimogene laherparepvec improves durable response rate in patients with advanced melanoma. J Clin Oncol 2015;33(25):2780–2788. Chesney J, Puzanov I, ... Found inside#4566 OncoVEXmGMCSF (HSV1 modified similarly to Talimogene Laherparepvec) in combination with CTLA4 blockade leads to both local and systemic efficacy in a ... Found inside – Page 2495.1 Talimogene Laherparepvec Talimogene laherparepvec (T-VEC; trade name: Imlygic) is an attenuated herpes simplex virus, type 1 (HSV-1), ... Found inside – Page 221Talimogene Laherparepvec Talimogene laherparepvec (T-VEC) is the first FDA-approved intralesional therapy for advanced, unresectable melanoma. Found inside – Page 537Talimogene laherparepvec (T-VEC) for the treatment of advanced melanoma. Immunotherapy. 2015;7(6):611–9. 107. Tazawa H, Kuroda S, Hasei J, Kagawa S, ... Found inside – Page 87Talimogene laherparepvec (T-VEC) as cancer immunotherapy. ... Talimogene laherparepvec (TVEC) and other oncolytic viruses for the treatment of melanoma. Found insideYou'll feel the confidence you'd hoped for as a future health professional. For patients and caregivers, this book provides a means to memorize medications to quickly and articulately communicate with your health providers. Found inside – Page 77Talimogene laherparepvec plus ipilimumab. • Active Comparator: Phase 2 Arm 2. Ipilimumab NCT02263508 Phase Ib/ III (recruiting, 2014) • Pembrolizumab ... Found inside – Page 176Talimogene laherparepvec (formerly known as OncoVEXGM-CSF) is a genetically modified HSV-1 virus deficient in ICP34.5 [130], and is in Phase 3 clinical ... Found inside – Page 623see General Patient teaching and advice for antineoplastic agents (p. 530) TALIMOGENE LAHERPAREPVEC (Imlygic) Available forms Vial: 1 × 106 PFU/mL, ... Found inside – Page 83Patients were given ipilimumab alone or in combination with talimogene laherparepvec. The objective response rate in the combination group was more than ... Puzanov I,... found inside – Page 288Talimogene laherparepvec improves durable response rate in patients with melanoma... 23Talimogene laherparepvec in combination with ipilimumab in Previously Untreated, Unresectable Stage IIIB-IV melanoma j, Puzanov,... 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