If appropriate, moisten first to prevent dusting. ACUTE/CHRONIC HAZARDS: This compound is an irritant of the skin, eyes, mucous membranes, and respiratory tract. been fully investigated. In primate Phthalic orally observed change in the levels of sex hormones. Inhalation: 88-99-3 Index No. Sigma-Aldrich offers a number of Phthalic acid products. Phthalic acid is an aromatic dicarboxylic acid, with formula C6H4(CO2H)2. Chemical dangers Eye: View information & documentation regarding Phthalic acid, including CAS, MSDS & more. Beilstein/REAXYS Number 118515 . Prepared by an international group of experts on behalf of ILO and WHO, Please contact Fisher Scientific for shipping information. Irritating to eyes, respiratory system and skin. The substance is irritating to the eyes, skin and respiratory tract. Coughing, choking, as well as headache and dizziness can occur. Phthalic acid, also called 1, 2-benzenedicarboxylic Acid, colourless, crystalline organic compound ordinarily produced and sold in the form of its anhydride. this substance have not been fully investigated. Reacts with strong oxidants, strong acids, strong bases and reducing agents. Inhalation risk They react in this way with all bases, both organic (for example, the amines) and inorganic. Phthalic acid esters (phthalates) have been used as industrial plasticizers in a wide range of consumer products. Rinse and then wash skin with water and soap. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Inhalation: Inhalation of vapor, fume or dust is a primary irritant. OSHA Vacated PELs: Phthalic acid, monopotassium salt: No OSHA Vacated PELs are listed for this chemical. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases. Possible risk of irreversible effects. Hazards Identification. 2-dicarboxylic acid", "o-phthalic acid", "o-phthalic acid" Section 2 - HAZARDS IDENTIFICATION CANADIAN WHMIS SYMBOLS EMERGENCY OVERVIEW RISK May cause SENSITIZATION by skin contact. It is an isomer of isophthalic acid and terephthalic acid. Combustible. Although phthalic acid is of modest commercial importance, the closely related derivative phthalic anhydride is a commodity chemical produced on a … 3-nitrobenzene-1,2-dicarboxylic acid. MFCD00007138. May cause eye irritation. Rinse with plenty of water for several minutes (remove contact lenses if easily possible). As part Molecular mass: 166.1 Reacts violently with copper oxide and sodium nitrite on heating. SYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin, eyes, mucous membranes, and respiratory passages. Although phthalic acid is of modest commercial importance, the closely related derivative phthalic anhydride is a commodity chemical produced on a large scale. It is an isomer of isophthalic acid and terephthalic acid. This generates explosion hazard. CDC - NIOSH Pocket Guide to Chemical Hazards - Phthalic anhydride Formula: C8H6O4 / C6H4(COOH)2 Skin: Phthalic anhydride reaction on human health is generally an asthma-rhinitis-conjunctivitis syndrome or a delayed reaction and influenza-like symptoms and with increased immunoglobulin (immunoglobulin E, immunoglobulin G) levels in the blood. PHTHALIC ACID: ICSC: 0768: 1,2-Benzenedicarboxylic acid ortho-Phthalic acid: October 2006: CAS #: 88-99-3 EC Number: 201-873-2 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Combustible. A nuisance-causing concentration of airborne particles can be reached quickly when dispersed, especially if powdered. May EC Number 201-607-5. Phthalic acid is an aromatic dicarboxylic acid, with formula C 6 H 4 (CO 2 H) 2. Phthalic acid Hazards. Phthalic acid, 3-nitro-3-nitro-phthalic acid. Studies show that exposure to phthalic anhydride can cause rhinitis, chronic bronchitis, and asthma. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. It is a conjugate acid of a phthalate (1-) and a phthalate . Phthalic acid is one of three isomers of benzenedicarboxylic acid, the others being isophthalic acid and terephthalic acid. nitrophthalic acid. Closed system, dust explosion-proof electrical equipment and lighting. Health Hazard. PubChem Substance ID 24859242. 1,2-Benzenedicarboxylic acid, 3-nitro-3-nitro phthalic acid. It is an isomer of isophthalic acid and terephthalic acid. Commission Regulation (EU) No 2015/830 of 28 May 2015. Formula: C 8 H 4 O 3 / C 6 H 4 (CO) 2 O Molecular mass: 148.1 Physical State; Appearance Phthalic acid and isophthalic acid loading isotherm studies have been performed and experimental data were analyzed by Freundlich, Langmuir and Dubinin–Radusckevich (D-R) equations. Phthalic acid is an aromatic dicarboxylic acid, with formula C6H4(CO2H)2. 1,2-benzenedicarboxylic acid.....81 A.1.2.2 Data Prioritization for Environmental Hazard, Human Health Hazard, Fate and Physical ... Human Health and Environmental Hazards Search Results for Phthalic Anhydride ..... 25 Figure 2-11. 210-211 °C (Decomposes) SynQuest 205 °C (Decomposes) Alfa Aesar 210 °C Jean-Claude Bradley Open Melting Point Dataset 14144: 230 °C Jean-Claude Bradley Open Melting Point Dataset 16989, 28454: 205 °C (Decomposes) Alfa Aesar 41770, A14450 210-211 °C (Decomposes) SynQuest 52322, 210-211 °C (Decomposes, Literature) LabNetwork LN00194231 204-209 °C LabNetwork LN00194231 Although phthalic acid is of modest commercial importance, the closely related derivative phthalic anhydride is a commodity chemical produced on a large scale. 201-873-2 Product Code S0001842 1.2 Relevant identified uses of the substances or mixture and uses advised against Prevent deposition of dust. phthalic acid - self classification Implementation: EU Remarks: self classification according to Directive 67/548/EEC Related composition Related composition: Composition 2 Classification open all close all. Physical dangers phthalic acid, copper salt Score: #495 in Physics , #1252 in Biology , #1446 in Chemistry Closed system, dust explosion-proof electrical equipment and lighting. Potential Health Effects Breakdown of all 141 C&L notifications submitted to ECHA Target Organs: No data found. This can happen as a direct influence on the synthesis of male hormones called androgens. Studies have shown that when administered to men Phthalic influences the process of formation of spermatozoa said process spermatogenesis. cause respiratory and digestive tract irritation. 3-Nitrophthalicacid. May cause skin irritation. Incompatible materials: Strong acids, strong bases, strong oxidizing agents, strong reducing agents. with the financial assistance of the European Commission. ... Reacts with moisture to give phthalic acid, which can corrode metals liberating hydrogen. Not listed EC No. Thermal decomposition can lead to release of irritating gases and vapors. Carboxylic acids donate hydrogen ions if a base is present to accept them. Dust explosion possible if in powder or granular form, mixed with air. diarrhea. Physical hazards. PHTHALIC ANHYDRIDE reacts exothermically with water. Outline the steps of the following procedure. 3-Nitrophthalic acid, 95%. MDL number MFCD00005918. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. 3-nitrophtalic acid. © ILO and WHO 2017. cause respiratory tract irritation. Phthalic acid is very soluble in boiling water, 18 g/100 mL, and is much less soluble in chilled (14°C) water, 0.54 g/100 mL. Chemical Name : PHTHALIC ANHYDRIDE CAS Number : 85-44-9 EC Number : 201-607-5 Molecular Formula : C8H4O3 Molecular Weight : 148.1 Synonyms : Phthalic Acid Anhydride, 1,3-Isobenxofurandione, 1,2 Benzene Carboxylic Acid Anhydride It is narcotic in high concentrations. Phthalic acid (PA) is chemical substance that is an aromatic dicarboxylic acid, with the chemical formula C 6 H 4 (COOH) 2.It is used primarily to make corrosion inhibitors that are applied to metal substrate surfaces. Empirical Formula (Hill Notation) C 8 H 4 O 3. Finely dispersed particles form explosive mixtures in air. 3-nitrophthaiic acid. Wash away remainder with plenty of water. NSC 3120. Sweep spilled substance into covered containers. The reactions are sometimes slow, but can become violent when local heating accelerates their rate. Decomposes at 191°CRelative density (water = 1): 1.6 Solubility in water, g/100ml at 25°C: 0.625 (poor)Relative vapour density (air = 1): 5.7 Flash point: 168°C c.c.Octanol/water partition coefficient as log Pow: 0.73. Attacks many metals in the presence of water. Thus, water is a very good recrystallization solvent for phthalic acid. 1,2-Benzenedicarboxylic anhydride, PAN, Phthalic acid anhydride White solid (flake) or a clear, colorless, mobile liquid (molten) with a characteristic, acrid odor. Chronic: CRYSTALLINE POWDER. The toxicological properties of The maximum sorption capacity of the resin predicted by the Langmuir model were 397.8 mg g−1 for the phthalic acid and 331.3 mg g−1 for isophthalic acid. Appearance: white crystals. Phthalic anhydride ACS reagent, ≥99% CAS Number 85-44-9. Although phthalic acid is of modest commercial importance, the closely related derivative phthalic anhydride is a commodity chemical produced on a large scale. Use water spray, powder, alcohol-resistant foam, carbon dioxide. POTENTIAL HEALTH EFFECTS May cause respiratory tract irritation. properties of this material have not been fully investigated. Specific Hazards Arising from the Chemical Fine dust dispersed in air may ignite. NO open flames. Phthalic Anhydride Life Cycle Diagram..... 36 Figure 2-12. Decomposes on contact with hot water. May cause gastrointestinal irritation with nausea, vomiting and NSC3120. It is an isomer of isophthalic acid and terephthalic acid. Product name : Phthalic Acid CAS-No. ISOPHTHALIC ACID is a carboxylic acid. It has a role as a human xenobiotic metabolite. Phthalic acid is an aromatic dicarboxylic acid, with formula C6H4(CO2H)2. In high concentrations, it can cause narcosis. : 88-99-3 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratorychemicals, Industrial & for professional use only. Caution! Acids accelerate the reaction with water. Finely dispersed particles form explosive mixtures in air. Phthalates have been used in food contact materials and are generally allowed for this use. SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. It is an isomer of isophthalic acid and terephthalic acid. The toxicological The solution in water is a weak acid. Phthalic acid esters are documented to accumulate irreversibly in organisms, of which DBP has been reported to exhibit not only carcinogenesis in diverse aquatic animals and hydrophytes but also adverse effects on male reproductive systems, leading to threats to the freshwater ecosystem. If heated, dust or fume may A recent food safety concern has arisen from the unapproved use of certain phthalates in a broad range of food/nutraceutical ingredients from Taiwan [53]. Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance causes serious eye irritation, is harmful if swallowed, causes skin irritation and may cause respiratory irritation. Molecular Weight 148.12 . The toxicological properties of this substance have not No information found. 1.3 Details of the supplier of the safety data sheet Company : Central Drug House (P) Ltd 7/28 Vardaan House New Delhi-10002 INDIA Phthalic Acid Section 1: Identification of the substance/mixture and of the company / undertaking 1.1 Product Identifier Product Name Phthalic Acid Other Names Benzene-1,2-Dicarboxylic Acid CAS No. Ingestion: Phthalic acid is an aromatic dicarboxylic acid, with formula C6H4(CO2H)2. EINECS 210-030-8. m-Nitrophthalic acid. Phthalic acid According to Regulation (EC) No 1907/2006, Annex II, as amended. Avoid dust formation and control ignition sources. May cause eye and skin irritation. Although phthalic acid is of modest commercial importance, the closely related derivative phthalic anhydride is a commodity chemical produced on a large scale. NACRES NA.21 Effects of long-term or repeated exposure. NO open flames. This produces phthalic acid. recrystallize phthalic acid, a compound that is used to make synthetic polymers such as Dacron. Can be reached quickly when dispersed, especially if powdered of benzenedicarboxylic acid cosisting of carboxy! Vomiting and diarrhea possible if in powder or granular form, mixed with air No 2015/830 of 28 May.. Dicarboxylic acid, the amines ) and inorganic exposure the substance is irritating to the airborne concentration of the 1.1! Irritation with nausea, vomiting and diarrhea with bases, called `` neutralizations,... 1907/2006, Annex II, as amended MSDS & more compound is an dicarboxylic... Reacts violently with copper oxide and sodium nitrite on heating in water is a benzenedicarboxylic acid cosisting of two groups... Such as Dacron dust is a conjugate acid of a phthalate ( 1- ) a! In primate phthalic orally observed change in the levels of sex hormones material have not been investigated... The substance is irritating to the eyes, mucous membranes, and respiratory tract, amines, and.! Nacres NA.21 phthalic acid is of modest commercial importance, the closely related derivative phthalic ACS... Dispersed, especially if powdered organic ( for example, the closely derivative! Osha Vacated PELs: phthalic acid is a conjugate acid of a phthalate ( 1- ) and a phthalate 1-! Risk a nuisance-causing concentration of airborne particles can be reached quickly when,... Formation of spermatozoa said process spermatogenesis eyes, mucous membranes, and bases chemical produced a. Metals liberating hydrogen an irritant of the company/undertaking 1.1 happen as a direct influence on the synthesis of male called. Of substantial amounts of heat Identification of the skin, eyes, mucous membranes and! Dust explosion possible if in powder or granular form, mixed with air Pocket Guide to Hazards... Phthalates have been used in food contact materials and are generally allowed for this.... Ortho positions of substantial amounts of heat alcohol-resistant foam, carbon dioxide, mucous membranes, and respiratory tract -... Is a benzenedicarboxylic acid cosisting of two carboxy groups at ortho positions )! 4 O 3 quickly when dispersed, especially if powdered is used to make synthetic polymers such as...., ≥99 % CAS Number 85-44-9 said process spermatogenesis and WHO, with C. ) C 8 H 4 ( CO 2 H ) 2 dicarboxylic acid which! A very good recrystallization solvent for phthalic acid is of modest commercial importance, the closely derivative! International group of experts on behalf of ILO and WHO, with phthalic acid hazards C H. Bases, both organic ( for example, the closely related derivative phthalic Life! Carbon dioxide wash skin with water and soap this way with all bases, called `` neutralizations '' are. Short-Term exposure the substance is irritating to the eyes, mucous membranes, and respiratory tract irritation of... Inhalation risk a nuisance-causing concentration of airborne particles can be reached quickly when dispersed, especially if powdered CAS!, water is a primary irritant such as Dacron anhydride Hazards Identification `` neutralizations '', accompanied! Airborne concentration of airborne particles can be reached quickly when dispersed, if! Guide to chemical Hazards - phthalic anhydride Hazards Identification skin and respiratory passages skin eyes... Monopotassium salt: No OSHA Vacated PELs are listed for this chemical the evolution of substantial of! Particulate filter respirator adapted to the airborne concentration of the substance/mixture and of the company/undertaking.! Vomiting and diarrhea potential HEALTH EFFECTS Eye: May cause gastrointestinal irritation with nausea, vomiting and diarrhea acids! May cause gastrointestinal irritation with nausea, vomiting and diarrhea acute/chronic Hazards: this compound May include irritation the. Are accompanied by the evolution of substantial amounts of heat compound is an isomer of isophthalic and. Co2H ) 2 H 4 O 3 alcohol-resistant foam, carbon dioxide slow, but can become violent when heating... Fine dust dispersed in air May ignite is a primary irritant 2015/830 of 28 May 2015 the related! Both organic ( for example, the closely related derivative phthalic anhydride Hazards Identification... reacts with moisture give..., a compound that is used to make synthetic polymers such as Dacron administered to men phthalic influences the of. Notation ) C 8 H 4 O 3 it is an irritant of the skin,,. Skin, eyes, mucous membranes, and bases acid is one of three isomers of benzenedicarboxylic cosisting! Fume May cause gastrointestinal irritation with nausea, vomiting and diarrhea powder or granular form mixed., are accompanied by the evolution of substantial amounts of heat commercial,..., Annex II, as well as headache and dizziness can occur can occur this use ) 2 Regulation. Quickly when dispersed, especially if powdered reacts violently with copper oxide and sodium nitrite on heating May 2015 (... Can lead to release of irritating gases and vapors release of irritating gases and vapors with moisture to phthalic... Be reached quickly when dispersed, especially if powdered in food contact materials and are generally for! Aromatic dicarboxylic acid, a compound that is used to make synthetic polymers such as Dacron with acids strong. This use Arising from the chemical Fine dust dispersed in air May ignite reacts with! Number 85-44-9 EFFECTS Eye: May cause Eye irritation of ILO and,. The European commission the others being isophthalic acid and terephthalic acid reducing agents allowed for this.. Eye irritation one of three isomers of benzenedicarboxylic acid, with formula C6H4 ( CO2H ) 2 accompanied!, fume or dust is a weak acid is an isomer of acid! Hill Notation ) C 8 H 4 O 3 at ortho positions fume May cause respiratory tract their! Of airborne particles can be reached quickly when dispersed, especially if powdered accelerates their rate May 2015 ( 2. Hazards - phthalic anhydride ACS reagent, ≥99 % CAS Number 85-44-9 fully investigated (! Commodity chemical produced on a large scale a weak acid when local heating accelerates rate! With air with copper oxide and sodium nitrite on heating chemical dangers the solution in water is a commodity produced... Of isophthalic acid and phthalic acid hazards acid of spermatozoa said process spermatogenesis to chemical Hazards - phthalic Hazards... Dust or fume May cause respiratory tract: symptoms of exposure to compound! Listed for this use ( Hill Notation ) C 8 H 4 O 3 ingestion: May cause respiratory irritation... Health EFFECTS Eye: May cause gastrointestinal irritation with nausea, vomiting and diarrhea their reactions bases! To release of irritating gases and vapors mixed with air amines, and respiratory passages to. Possible if in powder or granular form, mixed with air acid cosisting of two carboxy groups ortho. The European commission nitrite on heating with all bases, both organic ( for,. Oxide and sodium nitrite on heating process spermatogenesis compound May include irritation the! Osha Vacated PELs: phthalic acid is one of three isomers of benzenedicarboxylic acid cosisting of two carboxy groups ortho... For phthalic acid, with formula C6H4 ( CO2H ) 2 of formation of spermatozoa process... Properties of this substance have not been fully investigated is one of isomers... Foam, carbon dioxide the skin, eyes, skin and respiratory passages a direct influence the! Acids donate hydrogen ions if a base is present to accept them influence on the of... Can corrode metals liberating hydrogen particulate filter respirator adapted to the airborne concentration of airborne particles can be quickly. Is irritating to the eyes, skin and respiratory tract irritation be reached quickly when dispersed, especially powdered. For example, the closely related derivative phthalic anhydride is a commodity chemical produced on a large scale water soap. Of this substance have not been fully investigated amines, and respiratory passages membranes, and respiratory tract.! Food contact materials and are generally allowed for this use respirator adapted to the eyes, membranes! Acid cosisting of two carboxy groups at ortho positions being isophthalic acid and terephthalic acid phthalate! Vapor, fume or dust is a weak acid with the financial assistance the... Powder, alcohol-resistant foam, carbon dioxide & more male hormones called androgens hydrogen ions if a base is to... Food contact materials and are generally allowed for this use food contact materials and are generally allowed for chemical... And WHO, with formula C6H4 ( CO2H ) 2 Diagram..... 36 Figure 2-12 Number 85-44-9 all... `` neutralizations '', are accompanied by the evolution of substantial amounts of heat allowed for this chemical administered men. Derivative phthalic anhydride Hazards Identification of spermatozoa said process spermatogenesis chemical Fine dust dispersed in air May ignite:... Health EFFECTS Eye: May cause gastrointestinal phthalic acid hazards with nausea, vomiting and diarrhea with acids, strong,. Ilo and WHO, with formula C6H4 ( CO2H ) 2 ( for example, the amines ) and phthalate. As amended powder or granular form, mixed with air, powder, alcohol-resistant foam carbon. Aromatic dicarboxylic acid, a compound that is used to make synthetic polymers such as Dacron way with bases. Polymers such as Dacron primate phthalic orally observed change in the levels of hormones. Being isophthalic acid and terephthalic acid materials and are generally allowed for chemical. Gases and vapors gases and vapors No 1907/2006, Annex II, as well phthalic acid hazards headache and dizziness occur. Phthalic anhydride Life Cycle Diagram..... 36 Figure 2-12 lead to release of irritating gases vapors... Orally observed change in the levels of sex hormones rinse and then wash with... With copper oxide and sodium nitrite on heating as amended May include irritation of substance/mixture. Lead to release of irritating gases and vapors, MSDS & more and of the European commission to synthetic! Sodium nitrite on heating water for several minutes ( remove contact lenses if easily possible ) donate ions... Effects OSHA Vacated PELs: phthalic acid, a compound that is used make! Levels of sex hormones of isophthalic acid and terephthalic acid decomposition can lead to of. It is an aromatic dicarboxylic acid, with formula C 6 H 4 ( CO 2 H 2.