In addition, the book assesses the connections between, and among, the aforementioned topics, providing an integrated approach and in-depth understanding of how viruses work. Found insideThus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. Found insideThe ability to genetically engineer oncolytic viruses in order to minimize side effects and improve the selective targeting of tumor cells has opened up novel opportunities for treating cancer. While referencing advances in traditional therapies and treatments such as chemotherapy, this book also highlights advances in biotherapy including research using Interferon and Super Interferon, HecI based and liposome based therapy, gene ... Found inside – Page iThis book is a state-of-the-art overview of cancer regional therapy (CRT) for the surgeons and interventional radiologists active in CRT development and research. Found insideThis book elaborates on drug delivery targeting via intracellular delivery, specifically through the Receptor Mediated Endocytosis (RME) approach, due to the involvement of cellular receptors in various grave diseases. This book provides a comprehensive yet succinct overview of the current status of viral therapy of cancer. In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing ... Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses. This book covers everything from the epidemiology of the skin cancer, clinical presentation with clinical photographs, diagrams of the most common anatomical locations, to histological descriptions, special stains/tests for diagnosis, and a ... Found insideIn this book we provide insights into liver – cancer and immunology. An up-to-date overview of both basic research—including drug formulae, structure and biochemical activity—and clinical trials—usage and efficacy. Discusses future potential for treatment and development. Found inside – Page iThis book focusses on the different types of immunotherapeutics that are currently being used and developed for the treatment of melanoma. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final ... This book aims to provide a guide for virologists, translational researchers, and clinicians in the field of cancer research by providing reference protocols and methodologies from vector development through clinical translation. Immunotherapy is a rapidly evolving field that mandates frequent revision of the book as new insights to fight cancer emerge. It emphasizes methods, tools, and experimental approaches used by leaders in the field of translational gene therapy. The book promotes cross-disciplinary communication between the sub-specialties of medicine, and remains unified in theme. The book, drawing on data from the entire Italian experience as well as world literature, will be an outstanding benchmark for health professionals and researchers. A step-by-step, integrated approach for successful, FDA-approved combination drug products Using a proven integrated approach to combination drug development, this book guides you step by step through all the preclinical, clinical, and ... Found inside – Page 96Oncolytic virus-initiated protective immunity against prostate cancer. ... Helfand C. Amgen to Pursue T-Vec Approval Despite PhIII Survival Miss [Online]. Found insideThrough the comprehensive discussion of the topic, the book sheds valuable new light on the treatment of tumors. This book provides readers an extensive overview of recent progress in basic and clinical research on cancer immunotherapy. This translational book describes in detail the clinical application of novel approaches in cancer immunotherapy with the aim of educating clinicians in the implications of the most recent research and new developments in the field. Found insideThe authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize ... Drawn from extensive research, on-the-ground reporting, and personal experience, this book explores the fascinating role dogs (and cats) are playing in the search of cures for cancer. Found inside – Page 326oncolytic viruses (OVs) are multimodal therapeutics capable of not only lysing ... Amgen's T-VEC, a modified oncolytic herpes simplex virus encoding GM-CSF, ... Found insideThis open access book discusses the most current issues in head and neck cancer with a focus on current trends such as biomarkers, precision medicine and immunotherapy. This book will support your growth as a biotechnology professional. Found insideThe book begins with general reviews of gene therapy strategies with a focus on neurological disorders. The remainder of the chapters present approaches to specific neurological disorders. Found inside – Page 384TRADE NAMES Imlygic; T-vec CLASSIFICATION Immunotherapy CATEGORY Biologic response DRUG MANUFACTURER Amgen modifier agent; Oncolytic virus MECHANISM OF ... The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of ... Found insideStudying the epidemiology, identification, pathogenesis and clinical features of diseases associated with herpes simplex viruses, this important reference evaluates the latest treatment regimens, mechanisms of immune response and evasion, ... Found inside – Page 77Ipilimumab NCT02263508 Phase Ib/ III (recruiting, 2014) • Pembrolizumab (antagonist PD-1 mAb) • talimogene laherparepvec (oncolytic virus) MM Amgen A Phase ... Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding ... Found inside – Page 410One particularly strong type IIFN-inducing oncolytic virus is M mutated ... with oncolytic herpes simplex virus expressing GM-CSF, T-Vec® (Amgen Inc.), ... Found insideThis collection of chapters describes in detail the latest insights into the evaluation of resectability and neoadjuvant therapy to pancreaticoduodenectomy and distal pancreatectomy for pancreatic cancer. Found insideThe book contains virus-based tools and approaches in the fields of: i) DNA manipulations in vitro and in vivo; ii) Protein expression and characterization; and iii) Virus- Host interactions as a platform for therapy and biocontrol are ... Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. Herpes Simplex Virus: Methods and Protocols provides a wide collection of protocols employed in various levels of herpes virus research, including basic protocols on growing viruses in cell culture and cloning, manipulating and preparing ... Found insideThese are now considered foundational treatments for several solid tumor indications, and that list of indications is growing quickly. More broadly, antibodies have become workhorse molecules across the entire immunotherapy landscape. This book discusses the immunotherapeutic potential of Interleukin 12 in the context of clinical oncology, as well as antitumor effects confirmed in preclinical studies and clinical trials in cancer immunotherapy. Found inside – Page iiiThis book aims to provide an update on the advancements in the therapeutic arms race between cancer, clinicians and scientists alike to overcome resistance to targeted therapies. This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Found insideThis volume pays tribute to the late Wallace Rowe, Robert Huebner, and Maurice Hilleman whose initial discoveries of adenoviruses have tremendously enriched virology. Found insideThis work is the result of a partnership that began in 2011, when I received for the first time the invitation to be the scientific editor of a book on bone grafting, by the still little publisher known as InTech. The book helps the reader understand how cytokines network inside the tissues and highlights whether tissue-protection or exacerbation will be finally controlled. Found inside – Page 182Amgen acquired an oncolytic virus company called BioVex for a billion dollars in January 2011. More recent news seems to suggest that a phage will soon ... This book is the first to focus specifically on cancer nanotheranostics. Found insideThe guide contains many schematics and figures, vastly outnumbering the pages dedicated to text. This guide follows the sequence of a real clinical setting, going from the first screening visit to the final stages of terminal patients. Despite the competition, however, this book is a unique masterpiece and a must-have comprehensive resource for anyone interested in this area and for every medical library.” Score: 100, 5 Stars, Doody’s Medical Reviews Cancer ... The book starts with an analysis of the profound effect that viral epidemics had on world history resulting in demographic upheavals by destroying total populations. It also provides a brief history of virology and immunology. 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