5 = 14.66 g. Hence, Theoretical yield of Cinnamic Acid = 14.66 g. If reported Practical yield = 9.5 g. Then, Percentage Practical yield = Practical yield / Theoretical yield × 100 = 9. Structure, properties, spectra, suppliers and links for: (E)-4-Methoxycinnamic acid, 30-09-1, 830-09-1, 943-89-5. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. Puromycin 2HCl is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor. The percentage yield of the Cinnamic acid is about 64.8% of melting point 132 °C. Linear Formula C 6 H 5 CH=CHCOOH . Answers to questions you may have can be found in the inhibitor handling instructions. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. With the CAS number 140-10-3, it is also called trans-Cinnamic Acid, Phenylacrylic acid, Cinnamylic acid, 3-Phenylacrylic acid, (E)-Cinnamic acid, Benzenepropenoic acid, Isocinnamic acid. EC Number 205-398-1. (1 u is equal to 1/12 the mass of one atom of carbon-12) PubChem Substance ID 24848120 The solubilities of three cinnamic acid esters, namely, methyl ferulate, methyl p -coumarate, and methyl sinapate, in eight imidazolium-based ionic liquids composed of the PF 6− and BF 4− anions have been measured at (30, 39, and 48) °C. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. Der Gesamtgehalt von Phenolsäuren in Rapssamenmehl ist deutlich höher als bei anderen Ölpflanzen (z. B. Erdnuss: 63,6 mg/100 g, Raps: 639,9 mg/100 g). What is Cinnamic acid? BAPTA-AM is a selective, membrane-permeable calcium chelator. Cinnamic acid for synthesis. 2.Be sure to add the solvent(s) in order. Chemical Properties Cinnamic acid is almost odorless with a burning taste, and … © Copyright 2013 Selleck Chemicals. Cinnamic acid is a polyphenol and an antioxidant. 66 x 100 = 64.8%. Setanaxib (GKT137831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Structure, properties, spectra, suppliers and links for: Cinnamic acid, phenyl ester, 2757-04-2. trans-Cinnamic acid is a white crystalline organic acid, which is slightly soluble in water. All rights reserved, The mailbox will be used as the login user name and retrieve the password, (File Format: Jpg, Gif, Png, PDF,Zip,Txt,doc or xls Max Size: 3MB), 2-[3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol, LD50 (g/kg): 3.57 orally in rats; >5.0 dermally in rabbits (Letizia), high purity Cinnamic acid kf-wang(at)kf-chem.com, 3-Phenyl-2-propenoic acid (cinnamic acid). Cyclosporin A (Cyclosporine A) is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection. COVID-19 is an emerging, rapidly evolving situation. Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants.It exists as both a cis and a trans isomer, although the latter is more common. [2] Zhu B, et al. Tags: buy Cinnamic acid | Cinnamic acid supplier | purchase Cinnamic acid | Cinnamic acid cost | Cinnamic acid manufacturer | order Cinnamic acid | Cinnamic acid distributor, In vivo Formulation Calculator (Clear solution), Antineoplastic and Immunosuppressive Antibiotics, Selection Antibiotics for Transfected Cell, FDA-approved & Passed Phase I Drug Library, Human Endogenous Metabolite Compound Library, Anti-Cardiovascular Disease Compound Library, Cytoskeletal Signaling Pathway Compound Library, Endoplasmic Reticulum Stress Compound Library, Exosome Secretion Related Compound Library, Protein-protein Interaction Inhibitor Library, Small Molecule Immuno-Oncology Compound Library. In der Pflanze entsteht die Sinapinsäure als ein Produkt der Zimtsäurebiosynthese. Cinnamic acid has been reported to exhibit antioxidant and antibacterial activities [63–69]. 10.5 g of Benzaldehyde shall yield Cinnamic Acid = 148. Not for human use. It is created by the deamination of phenylalanine and it is then itself converted to any of the various polyphenols synthesized by plants. Cinnamic acid is freely soluble in benzene, diethyl ether, acetone, and it is insoluble in hexane. mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving. In this short piece of article, we shall be discussing more about the cinnamic acid At last,trans-Cinnamic acid… Cinnamic acid is an organic compound with the formula C 6 H 5 CH=CHCOOH. Beilstein/REAXYS Number 1905952 . Jump to main content Jump to site nav. Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. Cinnamic acid is an organic compound with the formula C6H5CH=CHCOOH. The solid solubilities of cinnamic acid, phenoxyacetic acid and 4-methoxyphenylacetic acid in supercritical carbon dioxide were measured using a semi-flow apparatus. expression of Bcl-2 (a marker of cell proliferation) is reduced, and apoptosis is induced by Cinnamic acid[2]. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. Treatment with GKT137831 suppresses reactive oxygen species (ROS) production. Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). CONCLUSION . Cinnamic acid exists in all living organisms, ranging from bacteria to humans. drug pre-dissolved in μL DMSO (Master liquid concentration The experiments were taken at 308.2, 318.2 and 328.2 K. The pressure range was from 11 to 24 MPa. An-Ci4 presented the highest AD value (6.61%), and An-Ci3 exhibited the lowest TAC value (50.16 mg/g). Enter the chemical formula of a compound to calculate its molar mass and elemental composition: Tip: Chemical formula is case sensitive. Ganciclovir (RS-21592, BW-759) is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay. Cinnamic acid could suppress the growth of colon carcinoma HT29 xenografts at well-tolerated doses. Phase 1. Cinnamic acid is also a kind of self-inhibitor produced by fungal spore to prevent germination. Cinnamic acid is an organic compound with the formula C6H5CHCHCO2H. To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'. Sinapinsäure kommt in der Natur vor allem in Rapssamen vor. Molecular Weight 148.16 . Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin), a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses. eCl@ss 39023931 . cinnamic acid solubility, Find Quality cinnamic acid solubility and Buy cinnamic acid solubility from Reliable Global cinnamic acid solubility Suppliers from mobile site on m.alibaba.com Cinnamic acid (Benzenepropenoic acid, Isocinnamic acid, trans-Cinnamic acid, Phenylacrylic acid), a naturally occurring aromatic fatty acid of low toxicity, induces cytostasis and a reversal of malignant properties of human tumor cells in vitro. It is a conjugate acid of a cinnamate. Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations. C Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. Thus, cinnamic acid exhibits a low toxicity. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol. In vivo studies indicate that acute lethal doses (LD50) of cinnamic acid is achieved at 160-220 mg/kg (ip) in mice, 2.5 g/kg (oral) in rats and 5 g/kg (dermal) in rabbits. Ausgehend von de… Get the latest public health information from CDC: https://www.coronavirus.gov. Method for preparing in vivo formulation:Take μL It is collected from the oil of cinnamon and is also found in shea butter. DMSO master liquid,next add μL Corn oil,mix and clarify. Cinnamic acid is an organic compound with the formula C6H5CH=CHCOOH. Cinnamic acid is a white crystalline acid with a molecular formula C 9 H 8 O 2. * When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online). It has a honey-like odour. Synonyms: trans-Cinnamic acid, Phenylacrylic acid, Cinnamylic acid, 3-Phenylacrylic acid|(E)-Cinnamic acid, Benzenepropenoic acid, Isocinnamic acid. 16 / 106. The antiproliferative activity of the drug is associated with caspase 9 activation, but not p53 phosphorylation, after 24 h treatment. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments. Visit ChemicalBook To find more trans-Cinnamic acid(140-10-3) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. 3.2.7Kovats Retention Index. Cinnamic acid (tCA) upregulates the expression of acetyl‑H3 and acetyl‑H4 proteins in a dose-dependent manner in treated cells and in the tumor tissue of treated mice. 12 x 10. Cinnamic acid shows genotoxic potential at both tested concentrations, inducing the formation of micronucleated cells[1]. The Selleck dilution calculator is based on the following equation: This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output ). Free Overnight Delivery on orders over $ 500 These are organic aromatic compounds containing a benzene and a carboxylic acid group forming 3-phenylprop-2-enoic acid. ). Cinnamic acid is a white crystalline compound with the formula C6H5CH=CHCOOH which is slightly soluble in water, and freely soluble in many organic solvents. MDL number MFCD00004369. ChEBI Ontology Outgoing trans-cinnamic acid (CHEBI:35697) has role plant metabolite (CHEBI:76924) trans-cinnamic acid (CHEBI:35697) is a cinnamic acid (CHEBI:27386) trans-cinnamic acid (CHEBI:35697) is conjugate acid of trans-cinnamate (CHEBI:15669) Instead of HPLC that is a costly and time-consuming method, a chemometric-based approach, net analyte signal standard addition method, was selected for simultaneous determination of CBZ and CIN … It exists as both a cis and a trans isomer, although the latter is more common. Tween 80,mix and clarify, next add μL ddH2O,mix and clarify. J Exp Clin Cancer Res. Note:1.Please make sure the liquid is clear before adding the next solvent. Cinnamic acid is a monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. This is normal and is due to slight batch-to-batch variations. Tel: +1-832-582-8158    Fax: +1-832-582-8590Email:[email protected], Tel: 030 4036821 90 (DE)    0207 4594182 (UK)Fax: 030 4036821 99 (DE)    0207 4594183 (UK)Email:[email protected]. GKT137831 partly inhibits ferroptosis. Thus, cinnamic acid exhibits a low toxicity, trans-Cinnamic acid, Phenylacrylic acid, Cinnamylic acid, 3-Phenylacrylic acid|(E)-Cinnamic acid, Benzenepropenoic acid, Isocinnamic acid, Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment). Catalog No.S3677 You can also browse global suppliers,vendor,prices,Price,manufacturers of trans-Cinnamic acid(140-10-3). The Selleck molarity calculator is based on the following equation: *When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages). Den größten Anteil an Phenolsäuren im Rapssamen macht mit 70 bis 85 % die Sinapinsäure bzw. It exists as both a cis and a trans isomer, although the latter is more common. CAS 140-10-3, chemical formula C₆H₅CH=CHCOOH. After acylating with lipophilic cinnamic acids, the lipid solubility of acylated bilberry anthocyanins significantly improved. Calculate the mass, volume or concentration required for a solution. cis-Cinnamic acid | C9H8O2 | CID 5372954 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. TLC and 1H NMR analysis confirm the purity of final product, without any cinnamic acid contamination, and thus it is not necessary to make any recrystallization. Is cinnamic acid polar or nonpolar? Cinnamic acid is an organic compound with the formula C 6 H 5 CHCHCO 2 H. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. [1] Niero EL, et al. LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. This could make cinnamic acid a potential biomarker for the consumption of these foods. Cinnamic acid has the formula C6H5CHCHCOOH and is an odorless white crystalline acid, which is slightly soluble in water. We do not sell to patients. (m3/ug)): Mackay model : 0.00074 Octanol/air (Koa) model: 0.0701 Fraction sorbed to airborne particulates (phi): Junge-Pankow model : 0.026 Mackay model : 0.0559 Octanol/air (Koa) model: 0.849 Atmospheric Oxidation (25 deg C) [AopWin v1.92]: Hydroxyl Radicals Reaction: OVERALL OH Rate Constant = 34.6013 E-12 cm3/molecule-sec Half-Life = 0.309 Days (12-hr day; 1.5E6 OH/cm3) Half-Life … Balsams such as storax An-Ci3 exhibited the lowest TAC value ( 50.16 mg/g ) acid in... 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